EVOLUTIONARY DEVELOPMENTAL BIOLOGY OF THE CORTEX

The mammalian cerebral cortex is a conspicuous structure which are characterized by tangential surface expansion and a six-layered laminar organization. How these anatomical hallmarks have been acquired during evolution? Mammals are derived from ancestral synapsids, a group of primitive amniotes lived at 3 hundred million years ago. To explore the origin and evolutionary process of the cerebral cortex, we perform comparative approaches for various amniote brains, and investigate cellular and molecular mechanisms underlying species-specific brain development. Our aims are to identify developmental programs shared in all amniotes, which are thought to be derived from common ancestor(s), and identify changes in the programs that provided mammalian specific neocortical structure.

 

Tadashi Nomura, PhD

Associate Professor
Developmental Neurobiology, Kyoto Prefectural University of Medicine
tel: +81-75-703-4941
e-mail: tadnom(at)koto.kpu-m.ac.jp

 

哺乳類大脳皮質の進化発生学

我々哺乳類の大脳皮質は、風船状に拡大しかつ6層の層構造を発達させています。このような特徴的な脳構造は進化の過程でどのようにして獲得されたのでしょうか?哺乳類は、約3億年前の単弓目と呼ばれる羊膜類(胚を包む膜の中で胎児が発生する動物群)から進化しました。我々は、現存する様々な羊膜類(マウス、ヤモリ、カメ、トリ)の胚操作・遺伝子改変技術を駆使して、羊膜類脳に共通の形質を明らかにするとともに、大脳皮質の進化に寄与した発生プログラムを解明します。

 

京都府立医科大学・神経発生生物学

准教授 野村 真 (nomura tadashi)

tel: 075-703-4941
e-mail: tadnom(at)koto.kpu-m.ac.jp